Fructosamine Test: Purpose, Procedure and Reference Range

A serum fructosamine test is done for the assessment of long-term glycemic control in patients with diabetes mellitus.

Updated: October 28, 2019


A serum fructosamine test is done for the assessment of long-term glycemic control in patients with diabetes mellitus. Diabetes mellitus (DM), commonly referred to as diabetes, is a group of metabolic disorders in which there are high blood sugar levels over a prolonged period. Symptoms of high blood sugar include frequent urination, increased thirst, and increased hunger. Fructosamine levels indicate the average level of blood glucose control over the past 2-3 weeks.
Fructosamine is a glycated protein similar to HbA1c, but the fructosamine test measures glycated protein in the blood instead of glycated hemoglobin. An increased level of serum fructosamine is associated with prolonged hyperglycemia for 2-3 weeks prior to testing in individuals with diabetes mellitus. The higher the fructosamine value, the poorer the degree of glycemia control. Sugar molecules that are present in your blood stick to proteins. These proteins circulate in your bloodstream for 14 to 21 days. So the amount of sugar in your blood for that time period can be measured by this test.
As fructosamine concentrations of people with well-controlled diabetes are usually found to be normal, this is not useful as a screening test for diabetes. The main advantage of the test is that it can detect overall changes in blood glucose control within a few weeks, rather than months like HbA1c. This test can be also useful when the HbA1c measurement may be unreliable.
However, fructosamine testing for diabetes management is rarely used in clinical practice. A simple blood glucose monitoring or HbA1c testing are preferred over it.

Purpose of Fructosamine Test:

Testing of serum fructosamine is done for monitoring of glycemic control in below cases:

  • To evaluate the effect of the change in diet, exercise, or medication in less then 6 weeks. It can and can help to monitor the effectiveness of the new treatments after just a few weeks rather than waiting months to do an A1c test.
  • When a narrow time frame is required, such as for ascertaining glycemic control at the time of conception in diabetic women who recently became pregnant
  • Conditions in which HbA1c may be unreliable, such as  sickle cell disease, hemolytic anemia, or recent blood loss

The test is also used in gestational diabetes because changes can happen very quickly during pregnancy.

Procedure of Fructosamine Test:

Fasting is not required for this test. A sample drawn from a vein or fingerstick and analyzed in a laboratory.

Reference Range:

Normal values vary in relation to the serum albumin concentration. The ranges are 200 to 285 µmol/L, when the serum albumin concentration level is 5 g/dL. Reduction in serum albumin lowers the serum fructosamine value.

Conditions that may affect the result:

All conditions that affect serum albumin production either increased or decreased may affect the result of fructosamine testing. These include:

  • Hepatic diseases, such as cirrhosis
  • Nephritic syndrome
  • Thyroid disease
  • Paraproteinemia

As high levels of ascorbic acid interfere with the fructosamine, patients should not take ascorbic acid supplements for a minimum of 24 hours prior to sample collection.


Related Articles

Hypopituitarism : Symptoms and Causes

Hypopituitarism : Symptoms and Causes

Hypopituitarism is a rare disorder of pituitary gland in which it either fails to produce one or more of its hormones or doesn't produce enough of them.

Chemical Pregnancy: Causes, Symptoms And Treatment

Chemical Pregnancy: Causes, Symptoms And Treatment

The reason it is known as chemical pregnancy is the initial stage of pregnancy, the only biochemical test will be able to detect the pregnancy.

Vaccines to Prevent Yellow Fever: Yellow Fever Vaccine

Vaccines to Prevent Yellow Fever: Yellow Fever Vaccine

Yellow fever is a serious disease caused by the yellow fever virus, found in certain parts of Africa and South America.

Blood Sugar Test or Blood Glucose Test : Purpose, Preparation, Procedure & Normal Range of Results

Blood Sugar Test or Blood Glucose Test : Purpose, Preparation, Procedure & Normal Range of Results

Blood sugar test or blood glucose test is done to know how well the body is managing blood sugar levels. Usually glucose testing is done to check for pre-diabetes, type 1 diabetes, type 2 diabetes, and gestational diabetes.

Diet for Gastroesophageal Reflux Disease GERD

Diet for Gastroesophageal Reflux Disease GERD

Diet modification and weight loss is recommended for patients diagnosed with GERD, if excess weight or obesity is an issue. You need to pay attention how carbohydrates, fats, and proteins affect digestion, as well as your GERD symptoms.

Shingles: Symptoms, Causes, Diagnosis, Treatment, Prevention and Complications

Shingles: Symptoms, Causes, Diagnosis, Treatment, Prevention and Complications

Shingles also called herpes zoster is a viral infection that causes a painful rash. Shingles is caused by reactivation of the varicella zoster virus, the same virus that causes chickenpox.

Complications of Appendicitis and Conditions That Mimic Appendicitis

Complications of Appendicitis and Conditions That Mimic Appendicitis

The appendix is a closed-ended, narrow, worm-like tube which is attached to the the first part of the colon called cecum. The wall of the appendix contains lymphatic tissue which is a part of the immune system. The inner lining of the appen

How Can You Lower Your HbA1C?

How Can You Lower Your HbA1C?

HbA1c is also referred to as haemoglobin A1c or simply A1c. The HbA1C is a blood test done to determine how well your diabetes management plan is working.

Suppliers Across World


Browse suppliers across the globe including Saint Helena, Benin, Slovakia, Latvia, Moldova, Trinidad and Tobago, Libyan Arab Jamahiriya, Zambia, Saint Pierre and Miquelon, Netherlands, Kenya, Ukraine, Chad, Central African Republic, Burundi, Mexico, Bahrain, Rwanda, Netherlands Antilles, Sierra Leone, Eritrea, Angola, North Macedonia, Mongolia, Estonia, Burkina Faso, Thailand, Isle of Man, Holy See (Vatican City State), Canada, Cyprus, Sudan, Timor-Leste, Swaziland, Fiji Islands, Greenland, Belize, Italy, Montenegro, SriLanka, Syria, Kiribati, Niger, Croatia, Falkland Islands, Marshall Islands, Lebanon, Algeria, Iraq, Anguilla and other localities of World as well..