Vaccine For Typhoid Fever: Inactivated and Live typhoid vaccine

Typhoid or typhoid fever is a serious disease caused by bacteria called Salmonella Typhi. High fever, fatigue, weakness, stomach pains, headache, loss of appetite, and sometimes a rash are the most common symptoms of typhoid.

Updated: December 15, 2017

Typhoid or typhoid fever is a serious disease caused by bacteria called Salmonella Typhi.  High fever, fatigue, weakness, stomach pains, headache, loss of appetite, and sometimes a rash are the most common symptoms of typhoid.
If it is not treated, it can be fatal. Usually, people get typhoid from contaminated food or water. Some people who get typhoid become carriers who can spread the disease to others.

Typhoid vaccines:

Typhoid vaccine can prevent typhoid. There are two vaccines to prevent typhoid. One is an inactivated or killed vaccine gotten as a shot. The other is a live, attenuated or weakened vaccine which is taken orally.

When and Who should get typhoid vaccine?

Typhoid vaccine is recommended for:

  • Travelers to parts of the world where typhoid is common.
  • People in close contact with a typhoid carrier.
  • Laboratory workers who work with Salmonella Typhi bacteria.

Inactivated typhoid vaccine (shot):

  • One dose of this vaccine should be given at least 2 weeks before travel. This will allow the vaccine to work in time. A single dose can protect you.
  • A booster dose is needed every 2 years for people who remain at risk.

Live typhoid vaccine (oral):

  • Four doses of this vaccine is recommended. one capsule every other day for a week. This can be taken on day 1, day 3, day 5, and day 7. The last dose should be given at least 1 week before travel to allow the vaccine time to work.
  • Swallow each dose about an hour before a meal with a cold or lukewarm drink. Do not chew the capsule.
  • A booster dose is needed every 5 years for people who remain at risk.

Either vaccine may safely be given at the same time as other vaccines.

Things and conditions to be considered before getting this vaccine:

Inactivated typhoid vaccine (shot):

  • Should not be given to children younger than 2 years of age.
  • Anyone who has had a severe reaction to a previous dose of this vaccine should not get another dose.
  • Anyone who has a severe allergy to any component of this vaccine should not get it. Tell your doctor if you have any severe allergies.
  • Anyone who is moderately or severely ill at the time the shot is scheduled should usually wait until they recover before getting the vaccine.

Live typhoid vaccine (oral):

  • Should not be given to children younger than 6 years of age.
  • Anyone who has had a severe reaction to a previous dose of this vaccine should not get another dose.
  • Anyone who has a severe allergy to any component of this vaccine should not get it. Speak to your doctor if you have any severe allergies.
  • Anyone who is moderately or severely ill at the time the vaccine is scheduled should usually wait until they recover before getting it. Tell your doctor if you have an illness involving vomiting or diarrhea.
  • Oral typhoid vaccine should not be given until at least 3 days after taking antibiotics.
  • Anyone whose immune system is weakened should not get this vaccine. They should get the typhoid shot instead. This includes anyone who:
  1. has HIV/AIDS or another disease that affects the immune system
  2. is being treated with drugs that affect the immune system, such as steroids for 2 weeks or longer
  3. has any kind of cancer
  4. is taking cancer treatment with radiation or drugs.

For more information speak to your doctor.

Risks from typhoid vaccine:

There are chances of side effects are usually mild and go away on their own. Serious reactions are also possible but are rare.
Some of the mild Problems following inactivated typhoid vaccine include:

  • Soreness, redness, or swelling where the shot was given
  • Fever
  • Headache

For live typhoid vaccine, mild reactions could be

  • Fever or headache
  • Stomach pain, nausea, vomiting or rash  which are very rare

Problems that could happen after any vaccine:

  • Sometimes people faint after vaccination. Sitting or lying down for about 15 minutes can help prevent fainting. If you feel dizzy, have vision changes or ringing in the ears, speak to your doctor.
  • In some cases severe pain in the shoulder and difficulty moving the arm where a shot was given could happen.
  • A severe allergic reaction would happen within a few minutes to a few hours after the vaccination.
  • There is a very remote chance of a vaccine causing a serious injury or death. The safety of vaccines is always being monitored. You can get all the information from Vaccine Safety site.

Signs of a severe allergic reaction can include hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, and weakness. These would start a few minutes to a few hours after the vaccination. If you have severe allergic reaction, very high fever, or behavior changes , call 9-1-1 or find the nearest hospital.
The reaction should be reported to the Vaccine Adverse Event Reporting System (VAERS) through the VAERS website or by calling 1-800-822-7967. VAERS is only for reporting reactions. They do not give medical advice.
If you are injured by a vaccine, you can file a claim in  National Vaccine Injury Compensation Program (VICP) by calling 1-800-338-2382 or visiting the VICP website to get the compensation.

Learn more about Vaccine:

Your doctor can give you the vaccine package insert or suggest other sources of information.
You can call your local or state health department or can contact the Centers for Disease Control and Prevention (CDC) by:
        Calling 1-800-232-4636 (1-800-CDC-INFO)
        Visiting  CDC vaccines website




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